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Based on these histological features the diagnosis was of oral MA

The typical maintenance dose is 1,000 mcg administered IM once monthly

Total weight loss at 48-68 weeks on the combination is difficult to predict without clinical trial data, but based on individual compound data (retatrutide at 24-28.7% and the additive benefit seen with CagriSema), a reasonable estimate for the combination is 25-35% total body weight reduction in high responders

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Gschl L, Scheinecker C, Bonelli M

Walitt, B