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For mental health, current evidence is also mixed

Basal insulin (such as insulin glargine or insulin degludec) can be added to existing oral regimens, including those containing Rybelsus or Januvia, though careful dose titration and glucose monitoring are essential to minimise hypoglycaemia risk

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Regular physical activity, as recommended by the UK Chief Medical Officers' Physical Activity Guidelines, helps maintain healthy weight and improves metabolic parameters relevant to both kidney and liver health

Repeated injection at the same site can cause lipohypertrophy (small fatty lumps under the skin) that affect peptide absorption