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During PD progression, microglia exhibit high plasticity, transitioning from a homeostatic surveillance state to various activation states that significantly influence DA-neuron survival

At the molecular level, PRP has been shown to upregulate several germ cell-specific genes involved in spermatogenic differentiation and maturation, including Dazl , Ddx4 , Pwil1 , Scp3 , Ccna1 , and Stra8 [65, 66]