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447 Moreover, these agents promote hemodynamic equilibrium, 18 diminish thrombotic propensity, 448 alleviate endothelial oxidative stress, 449 attenuate inflammatory processes, 450 and foster a favorable balance of the gut microbiota, 451 all of which collectively contribute to the salutary effects of these agents in patients with AS

While data specific to GLP-1 RA discontinuation remain limited, a large-scale prospective study on weight cycling (mean age 63.6 years, at high risk of T2DM) reported that weight regain was typically characterized by an adverse shift in body composition, with FM returning to baseline levels while FFM declined by 1.50 kg (95% CI 0.662.35)

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h , Bar graph summarizing the effect of NMDA-induced inward current after control (aCSF, n = 5 neurons), GLP-1 (50 M, n = 5 neurons), MK-801 (50 M, n = 5 neurons) or GLP-1MK-801 (50 M, n = 5 neurons)