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359,360 In the diabetic state, abnormalities in cellular energy metabolism affect macrovascular and microvascular lesions, 361,362,363 including abnormalities in substrate delivery to vascular EC or target organ cells (e.g., cardiac myocytes, thylakoid cells in glomeruli, and neurons and Schwann cells in peripheral nerves), conversion of the ratio of cell-specific fuel sources between glucose intermediates, fatty acids, and amino acids, changes in respiratory chain protein function, and uncoupling of respiratory chains

Zhonghua Er.Ke.Za Zhi

It's difficult to notice gradual changes when you see yourself daily

Psychiatry 66 , e99 (2023)

doi: 10.1155/2016/4579149 46 HanawaN.ShinoharaM.SaberiB.GaardeW

T., & Ciriolo, M