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doi: 10.1001/jama.2018.17749 92

While the vasodilatory effects of testosterone have been suggested in some studies, the mechanisms and the overall impact on cardiovascular health arent entirely clear

Similar to previous studies, lycopene improved endothelial function as measured by improved NO and reduced ET-1 release

Clinical trials test 0.16 to 4.5 mg subcutaneously once weekly (Lau 2021, Lancet)

Natural growth hormone secretion follows complex circadian and ultradian rhythms characterized by distinct pulses occurring approximately every 3-4 hours, with the largest pulses typically occurring during deep sleep phases