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Supplementary information Acknowledgements We acknowledge the contributions of the clinical staff of the Intramural Research Program of the National Institute on Drug Abuse, and the Clinical Research Unit of Johns Hopkins Bayview Medical Center, as well as the University of Maryland, Baltimore, a member of the Graduate Partnership Program, National Institutes of Health (NIH)

Yes, and doing so may offer multiple advantages

Roberge, J

Prior authorization is a requirement for many branded weight loss medications to be covered by insurance

Larger molecules like dulaglutide and albiglutide, which are fusion proteins with albumin or Fc domains, have molecular weights approaching or exceeding 60,000 Da, rendering them virtually impermeable to the BBB through classical routes

was an employee of Optum at the time the study was conducted.