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ER stress was also alleviated by impairing either TCA-dependent NADPH production or Glutathione Reductase

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Similarly, other members of the Clostridiales order, such as Eubacterium hallii , Faecalibacterium prausnitzii , and Anaerostipes caccae , have demonstrated the ability to boost CD8 + T cell activation and facilitate their infiltration into tumors, thereby enhancing the therapeutic response in solid tumors [103]