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Called GLP-1 receptor agonists (GLP-1RAs), the drugs were first developed to treat type 2 diabetes, but really took off when their potential as weight loss aids was recognized

The larger safety concern involves product quality, as compounded formulations do not undergo the same manufacturing oversight as FDA-approved products

Clinical trials have shown a significant weight reduction of about 15% over 68 weeks

The signal is widely reported but thinly studied

Importantly, behavioral gains were observed to regress after discontinuation of treatment, indicating that ongoing supplementation may be necessary to sustain benefits

Advanced methods in biochemical genetics and metabolomics over the past 65 years have shown that many metabolic changes can be found in children and adults with ASD, but the specific differences change by age, sex, and severity of symptoms 3,4,5,6,7,8,9