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Engineered GLP-1R-targeted nanoplatforms are reshaping precision therapeutics by extending incretin biology beyond conventional antidiabetic formulations [4]

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SomatomedinC mediates growth hormone negative feedback by effects on both the hypothalamus and the pituitary

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Therefore, while existing evidence supports low local toxicity, comprehensive in vitro and in vivo immunogenicity testing remains advisable prior to clinical translation [71, 191]