As recurrent red blood cell transfusions constitute the major source of secondary iron overload in MDS and AML patients, a more restrictive application should be considered
Direct glutathione (especially liposomal) provides faster and more targeted support
Secondary endpoints were defined as pharmacodynamics and pharmacokinetic parameters including maximum serum concentration, time to maximum concentration, half-life, plasma clearance, and volume of distribution, as well as exploratory parameters including bodyweight, glycemic control, and overall hormone profile
First, although HG exposure is widely recognized in the literature as a common in vitro model to mimic diabetes-induced cellular damage, it does not fully replicate the complexity of the DR
Properly manufactured Klow dissolves readily
Additionally, the long-term safety profiles remain undetermined