Topamax stops seizures when they first begin by preventing brain cells from working in overdrive
Common Side Effects (Both Drugs) Most Frequent (especially during first 4-8 weeks): Nausea (most common, affects 15-30% of patients) Vomiting (5-15% of patients) Diarrhoea (15-25% of patients) Constipation (10-20% of patients) Abdominal pain (8-15% of patients) Decreased appetite (expected effect) Fatigue or dizziness (5-10% of patients) Comparative Tolerability Mounjaro Considerations: Slightly higher rates of early GI intolerance (particularly at higher doses) Prescribing information includes warnings about severe gastrointestinal disease 12-15% discontinuation rate due to GI side effects in clinical trials Side effects increase with higher doses (10mg, 12.5mg, 15mg) Requires gradual dose escalation to minimise discomfort Ozempic Profile: Generally well-tolerated with gradual dose titration Lower discontinuation rates in some comparative studies More extensive long-term safety data (approved since 2017) Better patient compliance due to lower GI side effect burden Serious Risks (Both Medications) FDA and DCGI Warnings: Possible pancreatitis (inflammation of pancreas) Gallbladder disease (cholecystitis, cholelithiasis) Thyroid C-cell tumours (theoretical concern from animal studies) Gastroparesis (delayed gastric emptying rare but serious) Kidney problems (acute kidney injury in severe dehydration cases) Diabetic retinopathy (worsening of diabetic eye disease) Low blood sugar (hypoglycaemia, especially with insulin/sulfonylureas) Contraindications: Personal or family history of medullary thyroid carcinoma (MTC) Personal history of Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Known hypersensitivity to semaglutide or tirzepatide Severe gastroparesis or gastrointestinal disease Tips to Minimise Side Effects Start low, go slow Always begin with the lowest dose Eat smaller, more frequent meals Avoid large, fatty meals Stay hydrated Drink 2-3 litres of water daily Take with food Can help reduce nausea (though not required) Avoid trigger foods Greasy, spicy, or very rich foods Gradual dose escalation Dont rush to higher doses Communicate with your doctor Report persistent or severe side effects Treatment Protocols and Administration Ozempic Dosing Schedule Standard Titration: Weeks 1-4: 0.25mg once weekly (starter dose) Weeks 5-8: 0.5mg once weekly Week 9+: Increase to 1mg once weekly if additional glycaemic control needed Maximum dose: 2mg once weekly (if 1mg insufficient) Administration: Subcutaneous injection (tummy, thigh, or upper arm) Can be taken any day of the week, same day each week Can be taken with or without meals Rotate injection sites to prevent lipodystrophy Step-by-step guide on using injection pens Mounjaro Dosing Schedule Standard Titration: Weeks 1-4: 2.5mg once weekly (starter dose) Weeks 5-8: Increase to 5mg once weekly Weeks 9-12: Increase to 7.5mg once weekly (if needed) Weeks 13-16: Increase to 10mg once weekly (if needed) Weeks 17+: Can increase to 12.5mg or 15mg for maximum effect Administration: Subcutaneous injection Once-weekly dosing, same day each week More dosing flexibility for personalised treatment Requires careful click counting for accurate dosing Mounjaro KwikPen click counting guide Who Should Choose Which Drug
How vial size affects your unit calculations Vial size determines how much bacteriostatic water you add during reconstitution, which in turn determines your final concentration
Managing digestion helps prevent acid from rising into the mouth, which is a common cause of bitter or metallic taste during Wegovy use
During the interaction of the AEDG peptide with histone H3, 11 solutions were found at site 2, 8 solutions at site 3, 3 solutions at sites 5, 6 and 7, 4 solutions at site 8, and 1 solution at site 9
Trends Pharmacol Sci 32(2):8289
