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Similar to previously developed rodent models 20,21 , these results show that Glp1r S33W mice retain responsiveness to peptide-based GLP1RAs while gaining sensitivity to human-specific small-molecule GLP1RAs, establishing a valuable model system for investigating this next-generation class of drugs

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Liver tissues were harvested, weighed, and divided into two portions

Trans-activation of PPAR and induction of PPAR target genes by perfluorooctane-based chemicals

These combined mechanisms help lower blood glucose levels and support weight reduction in appropriate patient populations