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Serious but rare: Dependence, pulmonary hypertension, or valvular heart disease, especially in those with underlying cardiovascular conditions

The amygdala and medial prefrontal cortex (mPFC) are key brain regions responsible for anxiety processing networks

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Milk thistle may cause allergic reactions, particularly among people who are allergic to related plants (for example, ragweed, chrysanthemum, marigold, and daisy)