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Together, they provide a potent and selective model for investigating growth hormone dynamics, tissue repair, metabolism, and age-related endocrine decline in preclinical research

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Mitochondrial Ca 2+ overload due to MCU overactivation increases Ca 2+ sensitivity, enhancing myosin light chain phosphorylation and promoting contraction, and mitochondrial ROS activate redox-sensitive pathways such as MAPK and NF-B, driving VSMC proliferation and neointima formation

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doi: 10.3390/jcm9082531 332 Martnez-MartnezL-AMoraTVargasAFuentes-IniestraMMartnez-LavnM