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Recent Developments In September 2025, Eli Lilly released data showing orforglipron lowered A1C by 2.2 % vs 1.4 % for oral semaglutide at highest doses

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Second, by avoiding high peak concentrations followed by deep troughs, once-daily dosing may reduce the Cmax-related gastrointestinal side effects (nausea, vomiting) that are often associated with bolus-like GLP-1 exposure while maintaining sufficient trough concentrations for efficacy

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