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These investigators found that untreated Cushings disease patients had low GH and high IGF-I levels without clinical features of acromegaly, and after surgery with disease remission, serum IGF-I levels normalized

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The exact mechanism isn't fully understood, but the additional 5-7% weight loss demonstrates GIP's independent contribution beyond GLP-1 alone

Secondary: change in BMI, lipids, blood pressure, HbA1c, quality of life

Both are essential for normal cell division and successful fertilization

Consider antihistamines A daily over-the-counter antihistamine (such as cetirizine or loratadine) can ease symptoms in the short term, particularly during hayfever season