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In monkeys, sporadic abnormalities (vertebra, sternebra, ribs) occurred at clinically relevant exposures at the MRHD
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Against Naltrexone/Bupropion, observed associations with reduced incidence emerged for cataracts (HR 0.37, 95% CI: 0.180.75, p = 0.004), oculomotor binocular dysfunction (HR 0.46, 95% CI: 0.270.79, p = 0.004), dry eye disease (HR 0.36, 95% CI: 0.180.73, p = 0.003), and ametropic accommodative dysfunction (HR 0.50, 95% CI: 0.290.87, p = 0.012)
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Over a period of 4 to 8 weeks, as you move from the initial titration doses to higher therapeutic levels, the decrease in hunger becomes a steady state rather than a fluctuating feeling
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