Something other than weight loss was doing the work, and a lot of it is visible in your blood
Reduced Inflammation GLP-1 medications may: Lower inflammatory cytokines (like TNF- and IL-6) Shift immune cells toward a less inflammatory state This is important because lipedema tissue is characterized by chronic low-grade inflammation
Participants who achieved 5% weight loss by week 12 had an 87% chance of reaching at least 15% weight loss by week 48

Enhanced insulin signaling following weight loss has been associated with decreased circulating levels of pro-inflammatory cytokines, including IL-6, TNF-, and C-reactive protein, as well as improvements in endothelial and adipose tissue function ( In inflammatory arthritis, including PsA, improved insulin sensitivity has been independently associated with reduced disease activity and inflammatory burden, even after adjustment for changes in BMI ( Consistent with this concept, GLP-1RAs have been shown to directly modulate immune responses by reducing the secretion of key pro-inflammatory cytokines such as IL-6 and TNF-, which are central drivers of inflammation in both PsO and PsA ( 3.4 Early PsA and future research directions Despite the promising metabolic and immunomodulatory effects observed in PsO, the role of GLP-1RAs in PsA, particularly in its early stages, remains largely unexplored
GLP-1 medications work by slowing digestion and curbing appetite
Turn to over-the-counter helpers if needed, but consult a health pro first