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They cannot sense changes in the tissue microenvironment or adjust their activity, unlike stem cells, which adapt to the bodys needs

Users with longer treatment duration (6+ months) typically stabilize at plateau maintaining 40-60% of peak improvements, while short-term users (under 3 months) often continue gradual decline approaching pre-treatment baseline by month 4-6

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Impact of donepezil and memantine on behavioral and psychological symptoms of alzheimer disease: six-month open-label study