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It was speculated that this increase in DR risk with semaglutide OW in SUSTAIN 6 was due to the large and rapid reduction in HbA 1c levels, as observed with other existing therapies [58]

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Despite relatively high prevalence of both conditions and their debilitating impact on life (for example, one-quarter of ME/CFS patients are bed- or house-bound) [6], the understanding of mechanisms leading to the development of fatigue is poor

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