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doi: 10.1016/j.colsurfb.2019.110465

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But these compounded formulations, what makes them more likely to cause an overdose is that theyre being dispensed commonly in a vial and accompanied with that a needle and syringe, said Lambson

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To view or add a comment, sign in More Relevant Posts 1,2,3-Oxathiazolidine 2,2-dioxide, a five-membered cyclic sulfamidate has emerged as a powerful tool in modern medicinal chemistry, wherein it's Boc-protected derivatives in particular come across quite handy delivering Boc protected aminoethyl group under mild conditions Serving as highly effective aminoethylation reagents, the unique reactivity of cyclic sulfamidate stems from the strongly electron withdrawing SO group embedded within a strained heterocyclic framework, creating a highly activated electrophile that readily undergoes nucleophilic attack Compared to conventional ethylating agents, the approach avoids over alkylation issues seen with conventional ethylating agents and has proven especially valuable for the N-alkylation of challenging heterocycles, that also supports stereoselective introduction of chiral aminoethyl moieties using chiral derivatives and facilitates the synthesis of piperazine and morpholine fused framework as well