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Due to the heterogeneity in the included studies (I 2 = 83%, P = 0.003), the random effects model was used (Fig

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Mechanistically, GLP-1 receptor agonists may exert vascular protective effects by suppressing inflammation, limiting oxidative stress, and modulating key enzymes involved in extracellular matrix remodeling ( Matrix metalloproteinases, particularly MMP-9, together with their endogenous inhibitors (TIMPs), play central roles in extracellular matrix turnover and structural vascular remodeling ( The reduction in CRP, a recognized marker of aortic stiffness, medial degeneration, and systemic inflammation, further supports the anti-inflammatory profile associated with GLP-1RA therapy

This is called a dual-receptor mechanism , and it is what makes Mounjaro stand apart from other injections in this category

SGLT2 inhibitor or GLP-1 receptor agonist in type 2 diabetes