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42 Indeed, the high eNOS protein levels detected from 24 to 72 h in Gstp1/2 / mice suggests an enhanced NO production during this period of time

Dihexa pharmacological parameters Pharmacokinetic Parameter Mean SEM AUC0- (min^g/mL) 4471 1408 Vd (L/kg) 54.4 14.8 CpO ^g/mL) 87.3 31.9 tl/2 (min) 18256 7787 KE (min- l ) 0.00007 0.00004 CL (L/min/kg) 0.0026 0.0007 N=3 Table 10

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