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A phase 3 trial found that high-dose oral semaglutide (50 mg) produced a 12.7% placebo-adjusted weight loss at week 68, comparable to subcutaneous semaglutide in patients without diabetes

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Insurance companies typically negotiate fixed rates, and brand-name drugmakers have higher margins, allowing more flexibility

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Most people use them for areas like double chins, love handles, or thigh fat that wont shift even with a healthy diet and regular exercise

A separate rapid review published in Obesity Reviews in late 2025 by Jebeile and colleagues, which analyzed 25 studies, found that binge eating episodes and prevalence were reduced following treatment with liraglutide and semaglutide