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When collagen in the dermis is degraded by UV exposure, aging, or enzymatic activity (matrix metalloproteinases), KTTKS fragments are released as matrikines, endogenous signaling molecules that communicate tissue damage to dermal fibroblasts and trigger a repair response

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This biological infrastructure makes the gastrointestinal tract a natural target for peptide-based research and two compounds in particular have emerged with substantial published evidence: BPC-157 and KPV

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All these properties have been confirmed by clinical studies

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