Serious reactions are rare but possible
There was also no difference in adverse effects reported and no reports of ovarian hyper-stimulation syndrome, a potentially life-threatening condition associated with drugs stimulating ovulation
Blizzard RM, Hung M, Chandler RW, Aceto T Jr, Kyle M, Winship T
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In ovarian stromal cells of PCOS patients, LH enhances CYP17A1 phosphorylation via the cAMP/PKA pathway, upregulating 17-hydroxylase and 17,20-lyase activities and leading to excessive production of androstenedione and testosterone ( Moreover, excessive LHCGR activation may trigger premature luteinization of granulosa cells through ERK1/2-mediated phosphorylation, disrupting dominant follicle selection
Improved vectors and genome-wide libraries for CRISPR screening