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BEYOND WEIGHT LOSS: UNCOVERING GLUCAGON-LIKE PEPTIDE-1s JOINT EFFECTS GLP-1 agonists reduce the load on lower limb joints by treating obesity, 1 and protect against cardiovascular diseases

Synytsya A, Poukov P, Zadinov M, Troshchynska Y, ttina J, Synytsya A

TGF- pathway activation occurs with upregulation of TGF- superfamily genes for tissue repair, while simultaneously suppressing pathological TGF-1 secretion in fibrotic conditions

Whilst there is no formal contraindication preventing concurrent use, the combination requires careful consideration

Regulatory status: GLP-1s are off-label for alcohol use disorder, while naltrexone is FDA-approved as first-line treatment