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Zhong L et al

As compared to placebo, all doses of tirzepatide and semaglutide increased risk for gastrointestinal adverse events, with tirzepatide 15mg yielding the highest increased risk (3.6 times) for nausea, vomiting (4.4 times) and diarrhoea (double the risk)

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While your body produces glutathione, this production often isnt enough to overcome the surge in free radicals

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