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Distinct Growth Hormone Receptor Signaling Modes Regulate Skeletal Muscle Development and Insulin Sensitivity in Mice
Given the limited sample size and absence of external validation, ROC findings should be interpreted as exploratory and indicative of potential candidate biomarkers rather than definitive diagnostic markers
Further processing for Illumina sequencing was performed by the Cologne Center for Genomics as described in the following
N Engl J Med 373(23):22472257 Muskiet MHA, Tonneijck L, Huang Y, Liu M, Saremi A, Heerspink HJL et al (2018) Lixisenatide and renal outcomes in patients with type 2 diabetes and acute coronary syndrome: an exploratory analysis of the ELIXA randomised, placebo-controlled trial
The predominant subset was undifferentiated phenotype with dysregulated respiratory electron transport, suggesting that disruptions in both metabolism and mitochondrial function are involved
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