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Reported clinical-trial body weight reductions: 24.2% for retatrutide at 48 weeks, 22.5% for tirzepatide at 72 weeks (SURMOUNT-1), and 14.9% for semaglutide at 68 weeks (STEP 1)

For pharmaceutical research, IGF1 LR3 serves as a model compound for grasp how structural changes can enhance peptide therapeutics