Gelfman L, Bakitas M, Warner Stevenson L, Kirkpatrick J, Goldstein N, Ahluwalia S, Allen L, Allen K, Arnold B, Bakitas M, Bekelman D, Buck H, Dionne-Odom J, Dougherty C, Dunbar S, Evangelista L, Fahlberg B, Fendler T, Gelfman L, Goldstein N, Hanson L, Hauptman P, Karlekar M, Kavalieratos D, Kirkpatrick J, Kirkwood P, Kono A, Krumholz H , Kutner J, Lala A, Lindenfeld J, Mancarella G, Matlock D, Matzo M, Maurer M, Morrison S, O'Donnell A, Pamboukian S, Pinney S, Prince S, Reigel B, Ritchie C, Rogers J, Spertus J, Steinhauser K, Stevenson L, Strmberg A, Sudore R, Swetz K, Teuteberg W, Teuteberg J, Tucker R, Tulsky J, Wiegand D
The most frequently reported adverse reactions (1% or more and twice rate of placebo) were ECG voltage criteria for ventricular hypertrophy, tic, vomiting, psychomotor hyperactivity, insomnia, decreased appetite and rash [2 instances for each adverse reaction, i.e., 2/218 (1%)]
[8] [9] This supports the biological plausibility of topical delivery: the copper peptide can enter and dwell in the very layers where fibroblasts reside
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Also, several studies lacked full disclosure of variance measures or raw data, preventing the inclusion of potentially relevant findings
Xie JL, Grahl N, Sless T, Leach MD, Kim SH, Hogan DA, et al
