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Poor penetration of the BBB is the cause for attrition for 95% of drugs developed for neurological disorders

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Glutathione Peroxidase 1 Activity and Cardiovascular Events in Patients with Coronary Artery Disease 6

Ghusn W, Hurtado MD

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3 Extracellular matrix stiffness The extracellular matrix (ECM) is a key component of the tumor microenvironment, providing structural support and acting as a reservoir of cues, including biophysical signals such as matrix stiffness and viscoelasticity