Heading into 2026, several states have updated their rules, especially around weight management use
Best to consume 30 minutes before any physical activity
The FDA has flagged concerns about thyroid tumors, including medullary thyroid carcinoma (MTC), based on animal studies, though the risk to humans isnt fully understood
9597 Peripheral activation of GLP-1 receptors triggers a cascade of metabolic effects, including slowed gastric emptying, reduced appetite, lower hepatic glucose production, enhanced insulin synthesis and sensitivity, and improved cardiovascular functions such as vasodilation and cardiac output
Acknowledgements We acknowledge support from the National Institute on Alcohol Abuse and Alcoholism (AA029831), National Institute on Aging (AG057557, AG061388, AG062272, AG07664), from National Cancer Institute Case Comprehensive Cancer Center (CA221718, CA043703, CA2332216) Ethics declarations Competing interests The authors declare no competing interests
10.1016/j.intimp.2009.01.008 124 MiyazawaM.NakamuraY.IshikawaY
