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A final overnight fast of at least 8 h was required on day 15 before final pharmacodynamic measurements on day 16

The figure below shows the changes in A1C achieved by Ozempic and Mounjaro

No evidence of carcinogenicity was seen in rats following oral administration of topiramate for 2 years at doses up to 120 mg/kg (approximately 4 to 10 times the MRHD of QSYMIA based on AUC estimates)

After the vial is opened you can store medication in the refrigerator despite the label on the vial stating store in freezer. It is only required to be frozen prior to opening

Low fiber intake