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British journal of pharmacology, 179(4), 625641

Designed for in-vitro and mechanistic studies

doi:10.1113/jphysiol.2009.178053 Zozina VI, Covantev S, Goroshko OA, Krasnykh LM, Kukes VG

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Regarding the inconsistency of the aforementioned results, we hypothesize that it may be attributed to the following factors: (1) Drug structure and receptor binding specificity: Inherent variations exist in the molecular structure, half-life, and receptor binding efficacy among different GLP-1RAs, which directly determine their functional selectivity for atrial cardiomyocytes