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Both Semaglutide and Tirzepetide are GLP-1 receptor agonists, injectable medications that regulate appetite and insulin secretion

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By stabilizing electrical activity in the brain, it can help prevent seizures, and by dampening abnormal nerve signals, it can alleviate neuropathic pain

Compared to GLP-1, Exendin is more resistant to DPP-4 degradation, thus making it a more potent insulinotropic agent

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This was confirmed by the EPIC InterAct Case-Cohort Study which showed that obesity has a greater weight in defining the absolute risk of T2D than genetics [18]