Gooding, Locally delivered GLP-1 analogues liraglutide and exenatide enhance microvascular perfusion in individuals with and without type 2 diabetes
Using an integrated ligand and structure-based virtual screening pipeline, explicitly combining complementary ligand-based descriptors, multi-fingerprint similarity, electrostatic similarity, pharmacophore modeling, and multi-conformation docking under a consensus-driven selection strategy, we were able to identify three chemically distinct classes of GLP-1R agonist candidates: GQB47810, a non-peptidic molecule
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It supports insulin sensitivity, helps regulate fat distribution, and interacts with appetite-regulating systems in the brain
Leeuwenburgh C, Ji LL
Rev Endocr Metab Disord 15(3):181187 van Bloemendaal L et al (2014) GLP-1 receptor activation modulates appetite- and reward-related brain areas in humans
