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The use of CDK-inhibiting drugs, especially CDK4 and CDK6, induces cellular senescence by inhibiting the transition of the cell from the G1 to the S phase, simultaneously inhibiting its proliferation [81]

Continuing the protocol through at least four weeks before judging effectiveness remains important

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Recently, it was demonstrated that ferroptosis blockade significantly improved the estrous cycle disorder and prolonged the estrous cycle of primary ovarian aging by intraperitoneal injection of Fer-1 in Bnc1 mutant mice, and the ratio of oxidized to reduced lipids in the ovary was significantly reduced

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