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In May 2026, Lilly reported that in a late-stage trial of adults with obesity or overweight and at least one weight-related comorbidity, the highest 12 mg dose of retatrutide produced 28.3% average weight loss over 80 weeks, and more than 45% of participants lost 30% or more of their body weight

Zheng X, Chen T, Jiang R, et al

Conclusions OSA is one of the most common and serious sleep-related breathing disorders, which affects cardiovascular morbidity and mortality, as well as the quality of life [1, 3, 110]

For others, side effects such as nausea, vomiting and diarrhea force them to halt the medications, Dushay said

Some people do

In studies with rats and mice, Saxenda (liraglutide) and medicines that work like Saxenda (liraglutide) caused thyroid tumors, including thyroid cancer