Ongoing use may be needed to maintain weight loss, as stopping the medication often leads to gradual weight regain, especially in the absence of lifestyle changes
Thus, a systematic review of the efficacy of GLP-1RAs in terms of their effect on the underlying pathology of AD and improvement of cognitive functions, which included 6 articles that met the criteria (4 randomized control studies and 2 protocol studies) [53], indicates that GLP-1RA therapy in AD did not alter -amyloid and tau protein biomarkers and did not improve cognitive abilities, but demonstrated potential metabolic and neuroprotective benefits
This helps many patients lose weight and control blood sugar
at the end of the treatment, a 2.3 point improvement was noted in the exenatide group compared with a 1.7 point deterioration in the placebo group
Berberine is a plant compound that improves insulin sensitivity and may stimulate GLP-1 secretion, Bannan explains
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