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In this study, the difference in body weight reduction between tirzepatide- and semaglutide-treated groups can only partly explain the improvement in insulin sensitivity, lending support to the observation that tirzepatide was associated with improvements in insulin sensitivity associated with both body weight-lowering and a potential insulin-sensitizing effects of GIP
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These findings collectively emphasize that gut dysbiosis, increased intestinal permeability, and even gutlung microbial translocation can amplify neuroinflammation and worsen ischemic stroke outcomes, underscoring the need to consider the gutbrainlung axis as a potential target for improving stroke prognosis