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[PubMed]^2 Richie, J.P

Treatment of 4T1 cells with 10 M 4HT for 24 h significantly increased the conjugation of proteins at 65 kDa with 4HNE and this effect was partially blocked with the antioxidants, vitamin E and/or PMC (2,2,5,7,8-pentamethyl-6-chromanol, a vitamin E moiety without a lipid tail) (Fig

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As more comprehensive and longer-term human studies are conducted, a clearer understanding of long-term safety, potential interactions, and cumulative effects will continue to develop

Figure 2 Interestingly, many of the initial studies elucidating NRF2-ARE-mediated cellular protection utilized tert -butyl hydroquinone (tBHQ), a synthetic antioxidant and inducer of the NRF2 pathway via its auto-oxidized, electrophilic form tert-butyl benzoquinone (tBQ) (Rushmore and Pickett, 1990