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People who take CONTRAVE must not use any type of opioid, including street drugs, prescription pain medicines, cough, cold, or diarrhea medicines that contain opioids, or opioid dependence treatments, for at least 7 to 10 days before starting CONTRAVE

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doi:10.1371/journal.pone.0049392 Senior HE, McKinlay L, Nikles J, et al

However, this also means side effects and appetite suppression don't stop immediately when you pause or discontinue treatment