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Next steps in clinical translation First-in-human safety trials (phase I) are essential: to assess dose tolerability, pharmacokinetics, biodistribution, peptide half-life, clearance, immunogenicity
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WARNINGS Hypersensitivity Reactions Serious hypersensitivity reactions, including anaphylaxis, laryngeal edema, and bronchospasm have been reported following levocarnitine administration, mostly in patients with end-stage renal disease who are undergoing dialysis
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A few days after initiating these therapies he actually felt worse, and developed high blood pressure with 170/120 blood pressure, and had to stop the supplements
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