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Additional data come from studies on other immune disorders such as psoriasis, lichen planus, and vitiligo, where ROS contribute to the pathophysiology of the disease

These studies suggest that resveratrol might serve as an effective approach to improve ovarian functions and delay ovarian aging, and its specific effects and mechanisms are as follows: 1) increases nuclear factor erythroid 2-related factor 2 (Nrf2), a redox-sensitive transcription factor that regulates the expression of antioxidant genes (Espinosa-Diez et al., 2015), total glutathione (tGSH), SOD, and SOD2

Moreover, by protecting immune cells like T-cells, glutathione also boosts their function, reducing the risk of infection

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Figure 5 8.1 Estrogen and age-related inflammaging The pathogenesis of PMO is deeply intertwined with both age-related senescence and acute estrogen deprivation