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Heme-dependent metabolite switching regulates H2S synthesis in response to endoplasmic reticulum (ER) stress

It also acts as a powerful antioxidant, protecting against damage caused by pollution and UV exposure

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First characterized by Sikiric et al

According to the National Institutes of Health (NIH), liver toxicity from this combination is a leading cause of acute liver failure in the United States

[Apiaceae], type 2 diabetes, glycemic control, lipid regulation, dietary supplement, safety Citation Tawanwongsri W, Mordmuang A, Phenwan T and Siri-archawawat D (2025) Efficacy and safety of Centella asiatica (L.) Urb