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In addition, it increases the level of malondialdehyde (MDA) (an indicator of lipid peroxidation) and reduces the level of both reduced glutathione (GSH) and superoxide dismutase (SOD) in colonic mucosa, resulting in the disruption of the oxidant/antioxidant system and damage of the colonic mucosa (Cetinkaya et al

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Early combination therapy with oral glucose-lowering agents in type 2 diabetes

1 Baber RJ, et al

Although studies indicate that there is no interaction between these drugs, orlistat could indirectly reduce the availability of oral contraceptives, since there have been some specific cases of unexpected pregnancies