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It is to measure risk more accurately, think in cumulative exposure rather than 10-year probability, use apoB where standard markers are most likely to understate burden, intervene earlier when trajectory, family history, metabolic phenotype, or imaging warrant it, and keep treatment intensity proportional to both the evidence and the person in the consulting room

Blood work and monitoring may also be required to ensure safety and effectiveness

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Data availability Data is provided within the manuscript or supplementary information files

However, the absence of a direct interaction does not mean you can simply combine them without thought