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Thyroid tumors appeared in animal studies, though this hasnt been confirmed in humans

A further limitation was the fact that we did not assess associations between obesity class and other adverse health impacts known to be associated with overweight status, such as lifespan, quality of life and comorbidities 2,3,4,5,6,7,8,9,10

Normally, FOXO4 prevents p53 from triggering apoptosis in aging cells, allowing them to persist and contribute to age-related diseases (1)

In humans, there is some evidence suggesting that avoidance of vitamin D deficiency as well as vitamin D supplementation may be associated with a normal heart rhythm